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Precis Future Med > Epub ahead of print
DOI: https://doi.org/10.23838/pfm.2021.00072    [Epub ahead of print]
Published online August 23, 2021.
Non-thrombotic ischemic cerebrovascular events related to the use of tyrosine kinase inhibitors in patients with cancer: high-resolution magnetic resonance imaging findings
Jae Eun Sim  , Jeongho Park  , Oh Young Bang 
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Correspondence  Oh Young Bang ,Tel: +82-2-3410-3599, Email: neuroboy50@naver.com
Submitted: July 2, 2021  Accepted after revision: July 23, 2021
Abstract
The targeted cancer therapies that have been introduced in recent years are directed against cancer-specific molecules and signaling pathways, and thus, they have limited nonspecific toxicities. However, major vascular events, including stroke, are common in patients receiving tyrosine kinase inhibitors (TKIs). Inhibition of vascular endothelial growth factor receptor by some TKIs probably explains such events. Moreover, venous and arterial thromboses, atherosclerosis, and bleeding have been reported. Ischemic lesions can also occur due to impaired angiogenesis or endothelial dysfunction. However, the exact mechanisms of arterial stroke in patients with cancer receiving TKIs are unknown. Here, we have report two cases of non-thrombotic ischemic cerebrovascular events related to TKIs and described the high-resolution magnetic resonance imaging findings.
Keywords: Angiogenesis; Atherosclerosis; Neoplasms; Stroke; Tyrosine kinase inhibitors


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